ea0016p289 | Endocrine tumours | ECE2008
Trojanowicz Bogusz
, Brodauf Lars
, Sekulla Carsten
, Chen Zhouxun
, Bialek Joanna
, Radestock Yvonne
, Hombach-Klonisch Sabine
, Klonisch Thomas
, Finke Rainer
, Dralle Henning
, Hoang-Vu Cuong
AUF1/heterogeneous nuclear ribonucleoprotein D (hnRNPD) is an adenylate uridylate-rich elements (ARE) binding protein, which regulates the mRNA stability of many genes related to growth regulation, such as proto-oncogenes, growth factors, cytokines and cell cycle regulatory genes. Several studies demonstrated AUF1 expression in kidneys, liver, lymphoid tissues and melanocytes, and its involvement in apoptosis, tumorigenesis and development by its interactions with AREs bearing...